The integration of Cone-Beam Computed Tomography (CBCT) in endodontics has revolutionized diagnostic and therapeutic approaches, leading to enhanced precision and improved patient outcomes. This lecture, aims to explore the profound impact of CBCT technology on contemporary endodontic practice. It will discuss the fundamental principles of CBCT imaging and its superiority over traditional radiographic methods, particularly in identifying complex root canal anatomies, detecting periapical lesions, and planning surgical interventions. Through a series of detailed case studies, attendees will gain insights into the practical applications of CBCT, from initial diagnosis to treatment planning. By examining clinical scenarios and outcomes, this lecture will highlight how CBCT enhances diagnostic accuracy, facilitates minimally invasive procedures, and contributes to overall treatment success. Join me to delve into the transformative potential of CBCT in endodontics and discover how this cutting-edge technology is shaping the future of endodontic care.